Narcolepsy

What Causes Narcolepsy 

The primary cause of narcolepsy is the loss of neurons that produce hypocretin, a brain chemical essential for regulating wakefulness. This may be triggered by an autoimmune response.  

Genetics, infections, and stress are believed to play a role. Understanding narcolepsy causes helps shape accurate diagnosis and targeted treatment. 

Hypocretin Deficiency in the Brain 

Hypocretin (also called orexin) keeps you awake and alert by stabilising the brain’s sleep-wake rhythms. In narcolepsy, the brain loses the cells that produce this vital neurotransmitter, leading to unstable and unpredictable sleep-wake cycles.  

The deficiency causes people to shift suddenly from wakefulness to REM sleep, even during the day, often without warning. Measuring CSF hypocretin levels is key in narcolepsy diagnosis, especially for distinguishing Type 1 from other sleep disorders. 

Genetic and Environmental Risk Factors 

Certain HLA gene variants, especially HLA-DQB1*06:02, are strongly associated with narcolepsy. But genes alone don’t cause it, there’s no single switch. Environmental triggers like streptococcal infections, H1N1 flu, or severe psychological stress can tip the balance.  

In genetically predisposed individuals, the immune system may mistakenly attack hypocretin-producing neurons, disrupting the brain’s ability to regulate sleep. Understanding these narcolepsy causes helps guide both early detection, prevention strategies, and personalised treatment planning. 

‍Narcolepsy Type 1 and Type 2 Explained 

Type 1 narcolepsy involves sudden episodes of muscle weakness known as cataplexy, often triggered by strong emotions like laughter, surprise, or anger. It’s closely linked to low levels of hypocretin, a brain chemical crucial for staying awake and alert. 

Type 2 narcolepsy does not involve cataplexy and generally presents with normal hypocretin levels. However, individuals still face intense narcolepsy symptoms, including overwhelming daytime sleepiness, fragmented night-time sleep, and reduced quality of life without proper support, or narcolepsy therapy. 

Rehabilitation Programs and Support for Narcolepsy 

At Cadabam’s, we believe that managing narcolepsy is about more than medicine. Our rehabilitation programs include occupational therapy, behavioural coaching, and sleep hygiene counselling to help individuals regain confidence in daily life.  

From energy management strategies to memory aids, every intervention is tailored. With the support of neurologists, psychologists, and rehab experts, individuals can regain control, feel safe, and thrive despite the diagnosis. 

Living with Narcolepsy and How Cadabam’s Can Help 

Living with narcolepsy can feel overwhelming—especially when misunderstood. But you’re not alone. At Cadabam’s Bangalore, we offer comprehensive care with a team of narcolepsy specialists, including neurologists, psychiatrists, sleep technicians, and therapists.  

We design individualised treatment plans to improve your energy, safety, emotional wellbeing, and independence. Whether you’re seeking diagnosis, therapy, or long-term support, our approach combines science with compassion.  

We also provide safety education for families, workplace consultations, and relapse prevention tools to empower long-term healing.  

Our rehabilitation programs include behavioural coaching, sleep scheduling, and counselling tailored to your lifestyle and goals. Let’s work together toward a more balanced, wakeful life—where narcolepsy doesn’t define you, but support helps you thrive. 

If you are searching for a solution to your problem, Cadabam’s Rehabilitation Centre can help you with its team of specialised experts. We have been helping thousands of people live healthier and happier lives for 30+ years. We leverage evidence-based approaches and holistic treatment methods to help individuals effectively manage their Narcolepsy. Get in touch with us today. You can call us at +91 96111 94949.

How Narcolepsy Is Diagnosed 

Diagnosis begins with a thorough sleep history and physical exam. A Polysomnography (PSG) records brain and body activity overnight.  

This is followed by a Multiple Sleep Latency Test (MSLT) to measure how quickly the person falls asleep during the day. In some cases, CSF hypocretin testing is also used. If you're unsure about your symptoms, a narcolepsy test can help bring clarity.

Role of Sleep Studies and Daytime Testing 

Sleep studies are the gold standard for narcolepsy tests. Overnight Polysomnography (PSG) monitors breathing, muscle tone, eye movement, and brain activity to assess sleep architecture.  

The following day, the Multiple Sleep Latency Test (MSLT) evaluates how quickly a person falls asleep and how soon they enter REM—key markers of narcolepsy. Together, these tests help distinguish narcolepsy from other conditions and guide appropriate narcolepsy treatment, lifestyle adjustments, and safety planning. 

Differentiating Narcolepsy from Other Disorders 

Narcolepsy shares symptoms with conditions like idiopathic hypersomnia, obstructive sleep apnoea, or even depression, making diagnosis tricky. But unlike depression, narcolepsy causes sudden, uncontrollable sleep episodes, sometimes even during laughter or excitement.  

And while sleep apnoea leads to fatigue, it stems from interrupted breathing during sleep, not a neurological cause. Accurate testing by a narcolepsy specialist ensures diagnostic clarity and access to the most effective therapeutic path forward. 

Treatment Options for Narcolepsy 

There’s no cure, but narcolepsy can be managed effectively. A holistic approach combines medication, behavioural changes, and psychological support.  

At Cadabam’s Bangalore, we build personalised narcolepsy treatment plans to enhance safety, independence, and emotional wellbeing with the support of experienced neurologists and therapists. 

Stimulants and Wake Promoting Medications 

Doctors may prescribe Modafinil, Armodafinil, or low-dose amphetamines to boost daytime alertness and reduce excessive sleepiness. For managing cataplexy, treatments may include sodium oxybate, SSRIs, or tricyclic antidepressants, depending on individual needs.  

Each medication is carefully selected based on symptom severity, lifestyle demands, and side effect tolerance. With regular follow-ups and dose adjustments, your narcolepsy therapy remains both effective and tailored to your evolving needs. 

Lifestyle Modifications for Better Sleep Control 

Sleep schedules matter. Regular nap breaks, going to bed at the same time, avoiding caffeine and alcohol, and creating a wind-down routine can stabilise sleep patterns. 

Even small changes, like switching to blue light filters or setting alarms for naps, make a difference. At Cadabam’s, we guide each individual on realistic changes that align with daily life and work routines. 

Cognitive Behavioural Therapy for Sleep Disorders 

CBT helps people cope with the emotional toll of narcolepsy, especially the frustration, anxiety, depression, and social stigma it can bring. Therapy sessions focus on building resilience, developing healthy sleep routines, navigating daytime fatigue, and strengthening relationships impacted by the condition.  

Support groups further create space for shared stories, validation, and practical strategies. At Cadabam’s, structured CBT is a core part of our multidisciplinary narcolepsy therapy program, offering both emotional and behavioural support.