Alcoholism: When can suddenly ...

You went out last night. Did you had a drink. You feel like you’ve been drinking too much and you want to stop so you stop. Most people feel like that after a lot of occasional drinking. However, social or occasional infrequent drinking is not alcoholism. Suddenly stopping drinking can be a bad idea. If you […]

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Alzheimer’s Disease: Treatment...

Mrs. S’s 70-year-old husband forgot to pick the grandkids from school today. She did notice something has been up with him lately but just couldn’t understand what. Is old age catching up to him? He never remembers anything she tells him to do these days. Sometimes he has difficulty remembering names of some family members. […]

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10 Signs You May Have Obsessiv...

As per WHO (World Health Organisation), About 2% of the world’s population suffer from OCD which is roughly 1 in 50 people. OCD (Obsessive-Compulsive Disorder) is a type of anxiety disorder that causes obsessive and compulsive thoughts to a person. This article highlights the various types of symptoms that are associated with OCD. Listed below […]

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How to Stop Porn Addiction?

As most of us realize there is a great and lot deal of porn floating around the web these days. With porn so easy to come by it, there is also a little surprising fact that porn addiction is on the rise and no wonder how it is fueled. Many people will and may be […]

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Mystery of Motivation Thought

How many of us decided to wake up early & do the exercise or Yoga, just to stop after few days. How many of us enthusiastically stopped all cigarettes, started workup, guitar classes, aerobic training program… Etc.  Only to stop after a while, due to lack of motivation. We quickly lose motivation and stop pursuing […]

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Tricyclic Antidepression Drugs May Harm Health More Than Treating Depression

Tricyclic antidepressants such as amitriptyline, desipramine, and doxepin, may harm your heart, according to a new study conducted by researchers at University College London (UCL). This risk may extend beyond individuals who are being treated for depression, as these older antidepressants are also used to treat anxiety, sleep problems, headache, and back pain, among other conditions.
Although tricyclic antidepressants are one of the oldest classes of antidepressants, they are still used extensively, according to eMedExpert. Today, selective serotonin reuptake inhibitors (SSRIs) have replaced tricyclics as the treatment of choice for depressive disorders, primarily because patients tolerate them better and they are safer if taken in excess.
Researchers at University College London compared the use of tricyclic antidepressants with SSRIs or no antidepressant use in nearly 15,000 individuals in Scotland. Overall, the older antidepressants were linked with a 35 percent increased risk of cardiovascular disease, while use of SSRIs was not.
Based on these findings, Dr. Mark Hamer, senior research fellow in the Department of Epidemiology and Public Health at UCL remarked that they “suggest that there is an association between the use of tricyclic antidepressants and an increased risk of CVD that is not explained by existing mental illness.” The study results thus indicate that tricyclics have properties that are responsible for the greater risk.
Previous research has shown tricyclic use to be associated with a significantly higher rate of serious cardiovascular side effects, such as increased heart rate, as well as arrhythmias, blood pressure abnormalities, and congestive heart failure. They have also been linked with weight gain and diabetes, which are risk factors for cardiovascular disease.
The UCL study’s authors note that other factors may be involved in the possible link between tricyclic antidepressant use and cardiovascular disease. Hamer pointed out that individuals who take antidepressants are more likely to be overweight, smoke, and not get sufficient exercise, also risk factors for cardiovascular disease.
Before it can be determined with more certainty that tricyclic antidepressants can harm the heart, “there needs to be more research looking closely at the effects of these drugs on your heart,” notes Amy Thompson, senior cardiac nurse at the British Heart Foundation. Because antidepressants help a great many people, “it would be unwise for anyone taking them to stop based on the results of this study alone.”

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