Substance Abuse Rehabilitation

Substance abuse causes substance addiction. It is a chronic disease characterized by the compulsive need to seek sub irrespective of its harmful effects. It causes lasting changes in the brain. In order to recover and undo effects of the substance, the individual and his family members must undertake rehabilitative measures. Rehabilitation helps encourage the addicted […]

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10 Things people who have over...

Alcohol addiction is more than just a drinking problem. It is a biological, progressive, chemical and a fatal disease. It can enlighten a sense of urgency and necessity due to its dependence but overcoming an addiction is so entrenched it is not an easy feat. People who have overcome addiction have been sailed two ships; […]

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Depression in Women

One in four women experiences depression at some point in time in their life. And women are twice as likely to experience clinical depression than men. Still wondering why the women in your life are crying most of the time, or feeling persistently sad, and has no interest in anything. Here is your answer: she […]

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The Family Impact: The social disadvantage and subordination of women on the one hand. And the rapid socio-cultural and economic changes on the other have significantly altered traditional structures and institutions within society. Such changes are invariably associated with social upheaval and drug abuse is a known outcome of such change. Drug abuse poses various […]

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Reinventing Mindful Eating

Reinventing Mindful Eating: Eating is an inevitable activity of everyday life. There was a time when this activity was carried on with utmost mindfulness, i.e. prayers were offered before beginning the meals, and after ending the meals slokas like Annapoorne Sada Poorne, Shankara Prana Vallabhe, Trayam were recited. Offering supplication (Du’ä) by Islam followers during the meal, […]

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Tricyclic Antidepression Drugs May Harm Health More Than Treating Depression

Tricyclic antidepressants such as amitriptyline, desipramine, and doxepin, may harm your heart, according to a new study conducted by researchers at University College London (UCL). This risk may extend beyond individuals who are being treated for depression, as these older antidepressants are also used to treat anxiety, sleep problems, headache, and back pain, among other conditions.
Although tricyclic antidepressants are one of the oldest classes of antidepressants, they are still used extensively, according to eMedExpert. Today, selective serotonin reuptake inhibitors (SSRIs) have replaced tricyclics as the treatment of choice for depressive disorders, primarily because patients tolerate them better and they are safer if taken in excess.
Researchers at University College London compared the use of tricyclic antidepressants with SSRIs or no antidepressant use in nearly 15,000 individuals in Scotland. Overall, the older antidepressants were linked with a 35 percent increased risk of cardiovascular disease, while use of SSRIs was not.
Based on these findings, Dr. Mark Hamer, senior research fellow in the Department of Epidemiology and Public Health at UCL remarked that they “suggest that there is an association between the use of tricyclic antidepressants and an increased risk of CVD that is not explained by existing mental illness.” The study results thus indicate that tricyclics have properties that are responsible for the greater risk.
Previous research has shown tricyclic use to be associated with a significantly higher rate of serious cardiovascular side effects, such as increased heart rate, as well as arrhythmias, blood pressure abnormalities, and congestive heart failure. They have also been linked with weight gain and diabetes, which are risk factors for cardiovascular disease.
The UCL study’s authors note that other factors may be involved in the possible link between tricyclic antidepressant use and cardiovascular disease. Hamer pointed out that individuals who take antidepressants are more likely to be overweight, smoke, and not get sufficient exercise, also risk factors for cardiovascular disease.
Before it can be determined with more certainty that tricyclic antidepressants can harm the heart, “there needs to be more research looking closely at the effects of these drugs on your heart,” notes Amy Thompson, senior cardiac nurse at the British Heart Foundation. Because antidepressants help a great many people, “it would be unwise for anyone taking them to stop based on the results of this study alone.”

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